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The skin is our largest organ.

The skin is unique in many ways, but no other organ is so visible and demands so much attention and care in both diseased and healthy states.

About us

Dermaliq Therapeutics, Inc., is a dermatology and aesthetics company with a rich pipeline focused on follicular diseases and conditions. We are developing differentiated medical aesthetics, self-pay prescription, and OTC products.

Dermaliq’s mission is to develop a new generation of high-quality and user-friendly products with maximum efficacy and safety. Our unique “hyliQ®” technology overcomes the “delivery barrier” and for the first time enables the adsorption of multiple attractive active ingredients and drugs into the follicle and skin, enabling the development of “first in class” and “best in class” treatment options.

THERAPEUTIC FOCUS

Medical dermatology, aesthetics and follicular diseases

Skin and hair disorders are a leading cause of nonfatal disease burden worldwide and have a significant impact on a person’s well-being, mental health, ability to function, and social participation.

Topical, localized delivery of active ingredients to skin and scalp is the preferred route of treatment in most patients, reducing the risk of systemic side effects. Dermaliq’s transformative hyliQ® technology ushers in a new generation of topical products which offer not only superior dermal drug delivery for conditions like psoriasis and eczema but targeted delivery deep into hair follicles and sebaceous glands.

Specifically, hyliQ® technology consists of novel lipophilic excipients with lowest viscosity and surface tension which enables rapid penetration into follicles and the formation of active ingredient depots in the associated glands. This opens new avenues for topical treatment of many challenging dermatological conditions, including:

  • Alopecia: Hair loss that can occur in various patterns, including alopecia areata (patches of baldness) or androgenetic alopecia (male or female pattern baldness).
  • Folliculitis: Inflammation of hair follicles, often caused by bacterial or fungal infections.
  • Hirsutism: Excessive hair growth in women in areas where men typically grow hair.
  • Acne vulgaris: A condition where pimple-like bumps or keloid scars (comedones, papules, pustules, nodules) develop in the face or on the back of the neck.
therapeutics focus
focus on disease
focus on disease

Technology

The evolutionary hyliQ®– technology

hyliQ®, the unique and proprietary technology owned by Dermaliq, is designed to provide cutaneous drug delivery with unmatched bioavailability for a wide range of pharmaceutical actives.

The technology enables the development of superior liquid therapeutic drugs and medical skin care products which are characterized by exceptional cosmetic properties.

hyliQ® products do not require skin irritating excipients such as preservatives or penetration enhancers.

technology
technology

How it works

Proprietary hyliQ® carrier molecules transport solubilized active ingredients through the stratum corneum, preferably into the epidermis, into glands, or into hair follicles. By selection of specific carrier molecules, we can customize the properties of our drug products, enhancing targeted penetration into the skin tissues, increasing efficacy and reducing unwanted side effects.

dermaliq skin
hyliQ® – drug candidates

full dose is absorbed into skin and glands

Stratum Corneum

Epidermis

Dermis

Subcutaneous Tissue

Stratum Corneum

Epidermis

Dermis

Subcutaneous Tissue

Our Pipeline

Our goal is to establish a comprehensive pipeline of next-generation topical drugs and medical skin care products based on our proprietary hyliQ® technology.

DLQ01
  • Androgenetic Alopecia
    DLQ01 is a liquid topical with a prostaglandin (PG) F2alpha analog developed to stimulate scalp hair growth in men and women suffering from androgenic alopecia, also known as male and female pattern baldness.
    The randomized, blinded, vehicle-controlled Phase 1b/2a trial was started in December 2022 at Sinclair Dermatology, Melbourne Australia and is designed to evaluate the safety and efficacy profile over a 6-month treatment period of two dose strengths of DLQ01 and its vehicle and compared against the market product Rogaine® (Minoxidil) in men diagnosed with androgenic alopecia. A targeted total of 120 patients, 30 per treatment group, will be enrolled. Trial completion is expected in Q1 2024.
Pre­clinical Phase 1 Phase 2a Phase 2b Phase 3
  • Androgenetic Alopecia
    DLQ01 is a liquid topical with a prostaglandin (PG) F2alpha analog developed to stimulate scalp hair growth in men and women suffering from androgenic alopecia, also known as male and female pattern baldness.
    The randomized, blinded, vehicle-controlled Phase 1b/2a trial was started in December 2022 at Sinclair Dermatology, Melbourne Australia and is designed to evaluate the safety and efficacy profile over a 6-month treatment period of two dose strengths of DLQ01 and its vehicle and compared against the market product Rogaine® (Minoxidil) in men diagnosed with androgenic alopecia. A targeted total of 120 patients, 30 per treatment group, will be enrolled. Trial completion is expected in Q2 2024, and we plan to initiate two separate phase 2b studies, one in women and one in men, at the end of 2024.

DLQ01

DLQ02
  • Alopecia Areata
    Alopecia Areata (AA) is a chronic immune-mediated condition affecting up to 2% of the global population.

    It is characterized by autoimmune, chronic, and relapsing hair loss ranging from scattered patches to complete loss of hair, with significant psychological impact. At present, there are only two approved systemic drugs, which have a limited response rate. There is a high unmet medical need for safe topical applications, especially for mild and moderate forms of AA that only affect small areas of the scalp.

    DLQ02 is a liquid topical, calcineurin inhibitor with anti-inflammatory and immunomodulating properties, developed for the treatment of immune-mediated conditions. DLQ02 offers a dual mode of action, combining immunomodulation with hirsutism, which promotes additional hair growth.

    We plan to initiate a phase 2a study in Alopecia Areata by Q4/2024
Pre­clinical Phase 1 Phase 2a Phase 2b Phase 3
  • Alopecia Areata
    Alopecia Areata (AA) is a chronic immune-mediated condition affecting up to 2% of the global population.

    It is characterized by autoimmune, chronic, and relapsing hair loss ranging from scattered patches to complete loss of hair, with significant psychological impact. At present, there are only two approved systemic drugs, which have a limited response rate. There is a high unmet medical need for safe topical applications, especially for mild and moderate forms of AA that only affect small areas of the scalp.

    DLQ02 is a liquid topical, calcineurin inhibitor with anti-inflammatory and immunomodulating properties, developed for the treatment of immune-mediated conditions. DLQ02 offers a dual mode of action, combining immunomodulation with hirsutism, which promotes additional hair growth.

    We plan to initiate a phase 2a study in Alopecia Areata by Q4/2024

DLQ02

DLQ03
  • Bacterial soft tissue and skin infections
    DLQ03 is a liquid topical broad spectrum antimicrobial drug candidate for the treatment of skin and mucus infections with a focus on antimicrobial resistant strains and biofilm involvement, which is difficult to treat and even life-threatening.

    The randomized, single-center, double-blind, vehicle-controlled Phase 1b/2a trial was started in August 2022 at the Centre of Human Disease Research (CHDR), Leiden, The Netherlands, and is designed to evaluate the safety and efficacy profile of two dose strengths of DLQ03 and its vehicle in Atopic Dermatitis patients with a secondary Staph. Aureus infection.

    Trial completion is expected in Q2 2024.
Pre­clinical Phase 1 Phase 2a Phase 2b Phase 3
  • Bacterial soft tissue and skin infections
    DLQ03 is a liquid topical broad spectrum antimicrobial drug candidate for the treatment of skin and mucus infections with a focus on antimicrobial resistant strains and biofilm involvement, which is difficult to treat and even life-threatening.

    The randomized, single-center, double-blind, vehicle-controlled Phase 1b/2a trial was started in August 2022 at the Centre of Human Disease Research (CHDR), Leiden, The Netherlands, and is designed to evaluate the safety and efficacy profile of two dose strengths of DLQ03 and its vehicle in Atopic Dermatitis patients with a secondary Staph. Aureus infection.

    Trial completion is expected in Q2 2024.

DLQ03

Our Team

Management and Board of Directors

Frank Löscher, PhD

CEO, President & Co-Founder Dermaliq Therapeutics Inc.

Director

Oliver Schlüter, PhD

CFO & Co-Founder Dermaliq Therapeutics Inc.

Director (Chair)

Betsy Hughes-Formella, PhD

CSO & Co-Founder Dermaliq Therapeutics Inc.

Karen Liu, PhD

Founding partner 3E Bioventures Capital

Director

Christian Roesky, PhD

CEO Novaliq GmbH

Director

Robert J. Moccia

Independent Director

 

Scientific and Medical Advisory Board

Gordon J. Dow, Pharm.D.

Founder and former CTO/CEO Dow Pharmaceutical Sci. Inc.

Advisory Board

Xavier Yon

Former CEO Galderma  

Advisory Board

Michal E. Kuligowski, MD, PhD, MBA, iFAAD

VP, Dermatology, Clinical Research Group at Thermo Fischer Scientific, Inc.

Advisory Board

R. Todd Plott, M.D.

Chief Medical Officer Epiphany Dermatology

Advisory Board

Contact us

Head Office

Dermaliq Therapeutics, Inc.,
1201 North Market Street, Suite 111,
Wilmington, DE 19801, USA

German Subsidiary

Dermaliq Therapeutics GmbH
Im Neuenheimer Feld 515
69120 Heidelberg, Germany